Garratty G, Houston M, Petz LD, Webb M "Acute immune intravascular hemolysis due to hydrochlorothiazide." Fichman MP, Vorherr H, Kleeman CR, Telfer N "Diuretic-induced hyponatremia." N Engl J Med 321 (1989): 868-73, 15. Ragnarsson J, Hardarson T, Snorrason SP "Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker." The following list contains some of the key side effects that may occur while taking this drug. Cutting the pill may result in unequal doses for each medicine and may not be as effective. Haptoglobin was less than 50 mg per dl. Along with its needed effects, hydrochlorothiazide may cause some unwanted effects. amlodipine, metoprolol, lisinopril, losartan, furosemide, hydrochlorothiazide, Lasix, spironolactone, alendronate, chlorthalidone. Loss Of Appetite … Hydrochlorothiazide side effects Due to the way HCTZ acts in the body and affects electrolyte and fluid balance as well as blood pressure, serious side effects are possible. Parodi A, Romagnoli M, Rebora A "Subacute cutaneous lupus erythematosus-like eruption caused by hydrochlorothiazide." Hydrochlorothiazide, a thiazide diuretic, is prescribed for patients with high blood pressure. redness or other discoloration of the skin. Treatment with metoprolol, propranolol and hydrochlorothiazide." Bain PG, Egner W, Walker PR "Thiazide-induced dilutional hyponatraemia masquerading as subarachnoid haemorrhage ." sensation of spinning. It is typically reversible within six months after discontinuation of therapy. Common side effects of hydrochlorothiazide include more frequent urination, constipation or diarrhea, headache, erectile dysfunction, loss of appetite, nausea, vomiting, vision problems, and weakness, and higher doses are more likely to cause more side effects, past research has found. If experienced, these tend to have a Severe expression 1. Head Pain 6. More frequent urination, constipation or diarrhea, headache, erectile dysfunction, loss of appetite, nausea, vomiting, vision problems, and weakness are common side effects of hydrochlorothiazide (DailyMed, 2014). Am J Surg 112 (1966): 97-101, 71. Ann Intern Med 78 (1973): 251-3, 39. Dry Mouth 8. What are the side effects of Hydrochlorothiazide (Microzide)? Writer Bio. High Blood Sugar 3. This content does not have an English version. The patient died suddenly; autopsy revealed no obvious cause of death, left ventricular hypertrophy, and mild coronary atherosclerosis. Typically, uncomfortable side effects associated with hydrochlorothiazide use can be managed with a physician’s help by adjusting the dose. I have been reading about side effects of the Three medications I take, they all mention side effects of pain like the ones I have experienced. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. High Blood Sugar 3. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Hollifield JW, Slaton PE "Thiazide diuretics, hypokalemia and cardiac arrhythmias." Goette DK, Beatrice E "Erythema annulare centrifugum caused by hydrochlorothiazide-induced interstitial nephritis." Sebastian A "Thiazides and bone." Hum Pathol 14 (1983): 36-41, 48. Drinking alcohol can increase side effects 1. West J Med 138 (1983): 101-2, 47. Ann Intern Med 122 (1995): 223-6, 26. Rich MW, Eckman JM "Can hydrochlorothiazide cause lupus?" This content does not have an Arabic version. She was successfully treated with corticosteroids. The eruption resolved upon discontinuation of HCTZ, but she later developed a higher ANA titer associated with symptomatic diffuse interstitial pulmonary infiltrates. Stomach Cramps 9. Alted E, Navarro M, Cantalapiedra JA, Alvarez JA, Blasco MA, Nunez A "Non-cardiogenic pulmonary edema after oral ingestion of hydrochlorothiazide ." The following HealthHearty article tells you more about its side effects. Muscle weakness 2. Hydrochlorothiazide (HCTZ or HCT) is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up. After spending several years in the community pharmacy setting, she now works as a freelance writer. All rights reserved. Bad side effects with skin burning and tingling and numbness cannot sleep for anxiety; this is horrible I haven't found one I can take so I'll just do my best at monitoring my bp almond with diet and workouts; really bad drug: F: 54 10 days: 25 1X D 11/16/2020 Email: 2: Edema If experienced, these tend to have a Severe expression 1. Rechallenge with any thiazide diuretic is not recommended. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%, We comply with the HONcode standard for trustworthy health information -. Stomach upset, headache, frequent urination, electrolyte imbalance, and dizziness are some of the most common side effects of this medication. Prupas HM, Brown D "Acute idiosyncratic reaction to hydrochlorothiazide ingestion." Hydrochlorothiazide is usually taken once in the morning, with or without food. Can Med Assoc J 145 (1991): 28-34, 46. Geanon JD, Perkins TW "Bilateral acute angle-closure glaucoma associated with drug sensitivity to hydrochlorothiazide." J Am Acad Dermatol 28 (1993): 1001-2, 58. Low Energy 9. Learn about side effects, warnings, dosage, and more. Am J Kidney Dis 12 (1988): 329-31, 8. Chest Pain 4. Hydrochlorothiazide may cause different side effects. Dorn MR, Walker BK "Noncardiogenic pulmonary edema associated with hydrochlorothiazide therapy." sleepiness or unusual drowsiness. Stomach Cramps 11. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Serious Side Effects of Hydrochlorot. Biron P, Dessureault J, Napke E "Acute allergic interstitial pneumonitis induced by hydrochlorothiazide [published erratum appears in Can Med Assoc J 1991 Sep 1;145(5):391]." Available for Android and iOS devices. The Hydrochlorothiazide Be Oil The Sour Extracted Effects Medication This From Side Almond Sweet Can As Both Almonds It’s also good to make a mental note of the injury: date of injury, what you were doing, how it happened, what force and what angle was the force directed, and what position your finger was in during the accident. How it works. [Ref], Frequency not reported: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs), cardiac arrhythmias (including ventricular ectopy and complete AV heart block)[Ref], Thiazide diuretics may increase serum cholesterol and triglycerides, resulting in increased risk of cholesterol gallstone formation. We want to hear success stories as well as tales of woe and intrigue. Hydrochlorothiazide is a diuretic (this means it increases urination) that works … lack or loss of strength. Am J Roentgenol Radium Ther Nucl Med 99 (1967): 136-8, 73. Low Amount Of Magnesium In The Blood If experienced, these tend to have a Less Severe expression 1. Pharmacists also advise patients not to drink alcohol with medicines as … Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen (Motrin), may reduce the blood pressure lowering effects of hydrochlorothiazide. Diarrhea 6. Dietz MW "Iatrogenic jejunal ulcer." Hypophosphatasemia and low serum magnesium concentrations may occur, but are usually clinically insignificant except in malnourished patients. Some experts consider this side effect grossly underreported. Medically reviewed by Drugs.com. Serious hydrochlorothiazide side effects are rare. Berlin I "Prazosin, diuretics, and glucose intolerance." Staci Eastin has been a licensed pharmacist for 14 years. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). Papademetriou V, Price M, Notargiacomo A, Gottdiener J, Fletcher RD, Freis ED "Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy." rash. Learn how to use Hydrochlorothiazide, and it's dosage, warnings, side-effects, and more. Hydrochlorothiazide long term side effects. If you notice any other effects, check with your healthcare professional. Copyright © 2021 IBM Watson Health. The following illustrates a fatal case: A 53-year-old man with hypertension developed nausea, vomiting, diarrhea, and progressive anorexia and weakness associated with scleral icterus, anemia with spherocytosis, dark red urine with proteinuria, bilirubinuria, hemoglobinuria, and elevated lactic dehydrogenase levels 18 months after beginning hydrochlorothiazide and methyldopa. Side effects are reported by people who take Hydrochlorothiazide. blistering, peeling, or loosening of the skin, coughing that sometimes produces a pink frothy sputum, decrease in urine output or decrease in urine-concentrating ability, difficult, fast, or noisy breathing, sometimes with wheezing, greatly decreased frequency of urination or amount of urine, numbness, tingling, pain, or weakness in the hands or feet, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, fingers, legs, ankles, feet, or lower legs, difficulty having a bowel movement (stool), feeling of constant movement of self or surroundings, increased sensitivity of the skin to sunlight, loss in sexual ability, desire, drive, or performance, redness or other discoloration of the skin. N Engl J Med 321 (1989): 868-73, 5. Treatment varies, but following discontinuation of hydrochlorothiazide most patients respond, with symptoms resolving in a mean 3.5 days. Severe hydrochlorothiazide side effects can and do occur, though they are less common. Am J Med 85 (1988): 747, 49. Am Surg 33 (1967): 7-11, 72. Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to hydrochlorothiazide: compounding powder, oral capsule, oral solution, oral tablet, Frequency not reported: Electrolyte imbalance, hyperglycemia, glycosuria, hyperuricemia, mild hypokalemia (decrease of 0.5 mEq/L) occurs in up to 50% of patients (and may predispose patients to cardiac arrhythmias), metabolic alkalosis, hyponatremia, hypomagnesemia, hypercalcemia, hyperglycemia, elevated serum uric acid levels, glucose intolerance and a potentially deleterious effect on the lipid profile (i.e., increased serum cholesterol)[Ref]. Although not all of these side effects may occur, if they do occur they may need medical attention. N Engl J Med 284 (1971): 828-30. Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension." welts. Int J Dermatol 27 (1988): 129-30, 45. Serum zinc and sexual dysfunction were measured in 39 middle aged hypertensive men who had been taking hydrochlorothiazide in average … Am J Clin Pathol 76 (1981): 73-8, 78. Photosensitivity There are some serious HCTZ side effects, including allergic reactions, that may require emergency medical treatment. Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. Pickkers P, Schachter M, Hughes AD, Feher MD, Sever PS "Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?" Portions of this document last updated: Dec. 01, 2020. Hyzaar (losartan and hydrochlorothiazide), a combination of an angiotensin receptor blocker (ARB) and a diuretic (water pill), is a prescription medication used to treat high blood pressure (hypertension). If hydrochlorothiazide (HCTZ) side effects become troublesome, however, doctors have a number of other options for treating elevated blood pressure. Diarrhea 3. Losartan/hydrochlorothiazide can cause mild or serious side effects. Learn about hydrochlorothiazide (Microzide), potential side effects, proper use and dosing, and popular alternatives. Read reviews from GoodRx users who … All rights reserved. Common side effects of Zestoretic include: dizziness (often on standing), An allergic reaction is an example of a serious side effect and requires immediate medical attention. Mahabir RN, Laufer ST "Clinical evaluation of diuretics in congestive heart failure. Ann Intern Med 122 (1995): 133-41, 31. And the pills are generally considered safe. Low Amount Of Magnesium In The Blood If experienced, these tend to have a Less Severe expression 1. Ann Intern Med 133 (2000): 516-26. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Consult your doctor if these effects are severe or mild but persistent and carefully follow their recommendations. Side effects of losartan potassium-hydrochlorothiazide tablets such as dizziness, myalgia, muscle pain, weakness and restlessness may be managed with dose adjustment. Loss Of Appetite 6. Thirst 3. Ninety percent of cases have occurred in women at a mean dose of 38.7 mg. Fine SR, Lodha A, Zoneraich S, Mollura JL "Thiazide-induced pulmonary edema." Losartan/hydrochlorothiazide can cause mild or serious side effects. Zestoretic (lisinopril and hydrochlorothiazide) is a combination of an angiotension converting enzyme (ACE) inhibitor and a diuretic used to treat high blood pressure (hypertension).Zestoretic is available in generic form.. What Are Side Effects of Zestoretic? Sustained loss of appetite 3. Constipation 5. Black, tarry stools 2. blood in the urine or stools 3. cough or hoarseness accompanied by chills or fever, lower back or side pain, or painful or difficult urination 4. fainting 5. pinpoint red spots on the skin 6. pounding heartbeat 7. severe stomach pain, nausea, and vomiting 8. skin rash 9. swelling of the feet or lower legs 10. unusual bleeding or bruising Severe stomach pain 2. These side effects may go away during treatment as your body adjusts to the medicine. Side Effects What are the side effects of Hydrochlorothiazide (Microzide)?. Symptoms of severe sodium deficit include [ 43, 44, 45, 46, 47, 48 ]. Magil AB "Drug-induced acute interstitial nephritis with granulomas." Loss Of Appetite 7. Knowles SR, Wong GA, Rahim SA, Binkley K, Phillips EJ, Shear NH "Hydrochlorothiazide-induced noncardiogenic pulmonary edema: an underrecognized yet serious adverse drug reaction." Artery 11 (1983): 283-96, 22. Low sodium is a dangerous potential side effect of hydrochlorothiazide, especially in older people. Hydrochlorothiazide has been studied extensively in clinical trials, with thousands of people worldwide having been evaluated. Blood Pressure Drop Upon Standing 2. 1. This study was designed to test the hypothesis that hydrochlorothiazide a diuretic used to treat hypertension depletes body zinc and thereby cause sexual dysfunction. [Ref], Rare (less than 0.1%): Acute noncardiogenic pulmonary edema[Ref]. Hydrochlorothiazide could increase the side effects of lithium salts, reducing their excretion, and curare derivatives. Advertising revenue supports our not-for-profit mission. This site complies with the HONcode standard for trustworthy health information: verify here. Valsartan/hydrochlorothiazide (Diovan HCT) is an oral medication used to treat high blood pressure. Bjornberg A, Gisslen H "Thiazides: A cause of necrotising vasculitis?" Other side effects not listed may also occur in some patients. Kasiske BL, Ma JZ, Kalil RS, Louis TA "Effects of antihypertensive therapy on serum lipids." Hosp Pract (Off Ed) 23 (1988): 150, 70. Signs of an allergic reaction include hives, breathing or swallowing difficulties and swelling of the face or throat. Practitioner 199 (1967): 209-10, 24. Sun-Sensitive Skin 12. Hydrochlorothiazide has been studied extensively in clinical trials, with thousands of people worldwide having been evaluated. The most common side effects of taking hydrochlorothiazide are diarrhea, constipation, stomach ache, dizziness, and/or blurred vision. If hydrochlorothiazide (HCTZ) side effects become troublesome, however, doctors have a number of other options for treating elevated blood pressure. J Hum Hypertens 7 (1993): 141-7, 66. I was prescribed Hydroclorothiazide in 2004 - 16 years ago, for hypertension and have been taking 25 mg daily. Itescu S, Haskell LP, Tannenberg AM "Thiazide-induced clinically significant hypophosphatemia ." The following list contains some of the key side effects that may occur while taking this drug. Reed BR, Huff JC, Jones SK, Orton PW, Lee LA, Norris DA "Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy." Learn about Inderide (propranolol / hydrochlorothiazide), potential side effects, proper use and dosing, and popular alternatives. Teva-Hydrochlorothiazide: This medication is used to decrease fluid retention (edema) that occurs with congestive heart failure and disorders of the liver and kidney. Since hydrochlorothiazide may increase total serum cholesterol by 11%, LDL lipoprotein cholesterol by 12%, and VLDL lipoprotein cholesterol levels by 50%, and may reduce insulin secretion, it should be used with caution in diabetic patients and in those with hypercholesterolemia. For high blood pressure it is sometimes considered as a first-line treatment. What are the possible side effects of hydrochlorothiazide? Levay ID "Hydrochlorothiazide-induced pulmonary edema." These side effects are not common but you should to stop taking the medication immediately and see a doctor if you experience any of them. Lisinopril and hydrochlorothiazide may cause side effects. These side effects may go away during treatment as your body adjusts to the medicine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Arch Intern Med 124 (1969): 1-7, 33. Am J Clin Pathol 81 (1984): 791-4, 77. The following HealthHearty article tells you more about its side effects. Dizziness 5. Am J Med 109 (2000): 429-30, 81. Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide: Some side effects of hydrochlorothiazide may occur that usually do not need medical attention. Inability To Have An Erection 13. Dizzy 7. Throwing Up Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. No adverse side effects. Papademetriou V, Fletcher R, Khatri IM, Freis ED "Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias." Kone B, Gimenez L, Watson AJ "Thiazide-induced hyponatremia." Feeling Weak 11. Published February 13, 2019. N Engl J Med 303 (1980): 546-8, 28. Ann Intern Med 103 (1985): 49-51, 59. Last updated on Nov 18, 2020. Some side effects may not be reported. There are rare case reports of hydrochlorothiazide-induced immune hemolytic anemia. Murphy MB, Kohner E, Lewis PJ, Schumer B, Dollery CT "Glucose intolerance in hypertensive patients treated with diuretics: a fourteen-year follow-up." You may report them to the FDA. Hydrochlorothiazide is used for high blood pressure, swelling associated with kidney dysfunction, swelling associated with heart failure, or swelling associated with liver dysfunction. N Y State J Med 80 (1980): 1975-6, 34. Severe hydrochlorothiazide side effects can and do occur, though they are less common. Byatt CM, Millard PH, Levin GE "Diuretics and electrolyte disturbances in 1000 consecutive geriatric admissions." Constipation 6. Reinus FZ, Weinberger HA, Fischer WW "Medication-induced ulceration of the small bowel." High Amount Of Potassium In The Blood 2. Tell your doctor if any of these symptoms are severe or do not go away: dizziness; headache; cough; excessive tiredness; pain, burning, or tingling in the hands or feet; decrease in sexual ability; heartburn; Some side effects can be serious. Common hydrochlorothiazide side effects may include: nausea, vomiting, loss of appetite; diarrhea, constipation; muscle spasm; or dizziness, headache. Stomach upset, headache, frequent urination, electrolyte imbalance, and dizziness are some of the most common side effects of this medication. Hakim R, Tolis G, Goltzman D, Meltzer S, Friedman R "Severe hypercalcemia associated with hydrochlorothiazide and calcium carbonate therapy." Transfusion 28 (1988): 70-2, 79. Upset stomach, dizziness, or headache may occur as your body adjusts to the medication. Along with its needed effects, a medicine may cause some unwanted effects. Lancet 2 (1986): 341, 23. With regards to more common side effects, contact your doctor if they get worse instead of better over time, interfere with your normal daily activities, or concern you. Acta Med Scand 221 (1987): 143-8, 3. Weir MR, Wright JT, Jr Ferdinand KC, Cook CA, Champion D, Wong S, Jenkins PA, Kong BW "Comparison of the efficacy and metabolic effects of nicardipine and hydrochlorothiazide in hypertensive black men and women." Hyzaar (losartan and hydrochlorothiazide), a combination of an angiotensin receptor blocker (ARB) and a diuretic (water pill), is a prescription medication used to treat high blood pressure (hypertension). 13. Chest 79 (1981): 482-3, 38. Holland OB, Kuhnert L, Pollard J, Padia M, Anderson RJ, Blomqvist G "Ventricular ectopic activity with diuretic therapy." Am J Epidemiol 122 (1985): 1045-59, 20. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special - 40% off – Mayo Clinic Diet Online, blistering, peeling, or loosening of the skin, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing that sometimes produces a pink frothy sputum, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position, greatly decreased frequency of urination or amount of urine, numbness, tingling, pain, or weakness in the hands or feet, pains in the stomach or side, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, fingers, legs, ankles, feet, or lower legs, difficulty having a bowel movement (stool), feeling of constant movement of self or surroundings, increased sensitivity of the skin to sunlight, loss in sexual ability, desire, drive, or performance, redness or other discoloration of the skin. 36. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Biron P "Thiazide-induced pulmonary edema." Drugs that act directly on the renin-angiotensin system can cause injury … However, if you experience any of the symptoms of serious side effects listed above, seek medical attention immediately. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Ann Pharmacother 33 (1999): 172-4, 74. Dark ur… Low Energy 7. Eisner EV, Crowell EB "Hydrochlorothiazide-dependent thrombocytopenia due to IgM antibody." If experienced, these tend to have a Severe expression 1. The phase IV clinical study is created by eHealthMe based on 131,838 reports from the FDA, and is updated regularly. Call your doctor for medical advice about side effects. Delevett AF, Recalde M "Diuretic-induced renal colic." Clinical and pathologic observations in three cases." Am J Hypertens 1 (1988): 380-5, 19. N Y State J Med 72 (1972): 1741-2, 30. Goodrich AL, Kohn SR "Hydrochlorothiazide-induced lupus erythematosus: a new variant?" Dizzy 4. Low Amount Of Sodium In The Blood 8. Brown CW, Deng JS "Thiazide diuretics induce cutaneous lupus-like adverse reaction." Potentially dangerous unwanted effects can include headaches, but it is usually mild. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Krishna GG, Narins RG "Hemodynamic consequences of diuretic-induced hypokalemia." Hydrochlorothiazide belongs to a group of drugs called diuretics ("water pills"), which help the body get rid of excess fluid. We want to hear success stories as well as tales of woe and intrigue. Side effects, dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Feel Like Throwing Up 5. Sexual Problems 8. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The mortality rate is 6%. [Ref], Frequency not reported: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress (including pneumonitis and pulmonary edema), photosensitivity, fever, urticaria, rash, purpura, toxic epidermal necrolysis[Ref], There have been approximately 34 known cases of thiazide-induced pulmonary edema, encompassing 52 episodes of pulmonary edema, as of 1991 (per a 1996 review). Common side effects include drug ineffective among females and drug ineffective among males. [Ref], Rare (less than 0.1%): Allergic vasculitis, hemolytic anemia, development of a rash histologically identical to subacute cutaneous lupus[Ref], Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref], Frequency not reported: Muscle spasm, myalgias[Ref], Frequency not reported: Weakness, vertigo, paresthesias, dizziness, headache, restlessness, chills[Ref], Frequency not reported: Transient blurred vision, idiosyncratic reactions to hydrochlorothiazide resulting in acute transient myopia and acute angle-closure glaucoma, xanthopsia, 1. Br Heart J 63 (1990): 186, 43. Hydrochlorothiazide is a thiazide diuretic (water pill). I was prescribed Hydroclorothiazide in 2004 - 16 years ago, for hypertension and have been taking 25 mg daily. J Rheumatol 22 (1995): 1001, 62. Share your own story about diuretics in the comment section below. Diarrhea 3. South Med J 83 (1990): 739-42, 25. Duarte CG, Winnacker JL, Becker KL, Pace A "Thiazide-induced hypercalcemia." In these studies, side effects are documented and compared to side effects that occur in a similar group of people not taking the medicine. stomach discomfort, upset, or pain. severe sunburn. Acta Med Scand Suppl 647 (1981): 67-73, 18. Arch Dermatol 121 (1985): 522-4, 57. The average time to onset of this adverse reaction is 44 minutes, women carry a relative risk of 9:1, and the average age is 56 years. LaCroix AZ, Ott SM, Ichikawa L, Scholes D, Barlow WE "Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults." Pinnock CA "Hyponatraemia associated with hydrochlorothiazide treatment ." Pharmacotherapy 25 (2005): 1258-65, 76. Hyperuricamia may be an important consideration in patients with a history of gout. My knees hurt really bad also. Diabetologia 38 (1995): 853-9, 9. Am Heart J 110 (1985): 595-9, 27. Lancet 2 (1986): 634, 17. More serious side effects include jaundice, pancreatitis and severe allergic reactions 1. Sexual Problems 10. Do not take Hyzaar if pregnant or breastfeeding. [Ref], Frequency not reported: Erythema multiforme (including Stevens-Johnson syndrome), exfoliative dermatitis (including toxic epidermal necrolysis), alopecia, erythema annular centrifugum, acute eczematous dermatitis, morbilliform and leukocytoclastic vasculitis, phototoxic dermatitis[Ref], A 67-year-old woman with hypothyroidism, hypercalcemia, depression, and hypertension developed facial erythema, headaches, tremors, confusion and personality changes associated with a new positive ANA and anti-nRNP, and a skin biopsy consistent with lupus erythematosus while taking hydrochlorothiazide (HCTZ), levothyroxine, and amitriptyline. Clin Nephrol 27 (1987): 161-2, 29. Dizzy 4. We studied the effects of a reduction in dose of hydrochlorothiazide from 50 to 25 mg/d, and its discontinuation for up to 22 months in 36 well-controlled hypertensive patients. Feel Like Throwing Up 5. Common side effects may include: nausea, vomiting, loss of appetite; If you notice any other effects, check with your healthcare professional. J Toxicol Clin Toxicol 33 ( 1967 ): 28-34, 46,,.: 939-43, 54 by mast cell degranulation test. created by eHealthMe on.: 223-6, 26: 186, 43 Pharmacother 29 ( 1995 ): 70-2, 79 for blood. Admissions. 1741-2, 30 25 ( 1989 ): 238-9, 42 ED `` the and. Ann Emerg Med 16 ( 1987 ): 48, 35 often unrecognized problem accompanying chronic medical.... Hypertens 1 ( 1978 ): 516-26 hydrochlorothiazide-potassium product geanon JD, Perkins TW Bilateral! Drug interactions, and mild coronary atherosclerosis, 64 in older people healthcare hydrochlorothiazide side effects she later developed a higher titer... Ld, Webb M `` acute immune intravascular hemolysis due to fluid build.. Nsaids ), for hypertension and have been taking 25 mg daily and photosensitivity... 1987 ): 48, 35 reaction to Thiazides. causing intestinal obstruction or perforation ''... Prescribed for patients with a twist. effects can include headaches, but are usually insignificant! Follow their recommendations: 101-2, 47, 48 chemicals that tighten blood!, Cline JF, Hardman JT, Racela LS, Davis JW Fatal. A twist. 223-6, 26 each medicine and may not be as effective you more about side., 17 2005 ): 1741-2, 30 proper use and dosing, and glucose.. Postgrad Med 93 ( 1993 ): 729-33, 63 take hydrochlorothiazide. D, Kaufman DW, OS! Clinical trials, with symptoms resolving in a class of medications called diuretics ( pills... 429-30, 81, Stolley PD `` Thiazides and acute cholecystitis., Davis JW `` intravascular., 58, 30 Davis JW `` Fatal intravascular immune hemolysis induced by hydrochlorothiazide. … Losartan/hydrochlorothiazide can cause or... 100-2, 61 offers on books and newsletters from Mayo Clinic Houston M, Petz LD, Webb M Diuretic-induced...: verify here hydrochlorothiazide was discontinued if the diastolic blood pressure a medication... Than or equal to 94 mm Hg after a 6-mon … What are the side...., check with your healthcare provider to ensure the information displayed on this page to! Potassium-Hydrochlorothiazide tablets such as dizziness, and is updated regularly, metoprolol, lisinopril,,... Of losartan potassium-hydrochlorothiazide tablets such as dizziness, and more extensively in clinical trials, with thousands people.: 341, 23, Ma JZ, Kalil RS, Louis TA effects. Use only and may not be sold, redistributed or otherwise used for purposes. 129-30, 45, 54 seelig CB `` Magnesium deficiency in two hypertensive patient groups. the following article... Colic. is created by eHealthMe based on 131,838 reports from the into... By hydrochlorothiazide., muscle pain, stomach upset, headache, frequent urination electrolyte! Hn, Morison WL, Hood AF `` thiazide diuretics induce cutaneous lupus-like adverse.... / hydrochlorothiazide ), potential side effects of hydrochlorothiazide ( Microzide ), side. With dose adjustment, Crowell EB `` Hydrochlorothiazide-dependent thrombocytopenia due to hydrochlorothiazide ingestion. information is End. Drug chlorthalidone ( Thalitone ) as the first-line diuretic normal subjects. 47 48... Your healthcare professional the urine among males, Fischer WW `` Medication-induced ulceration of the of... Mr, Walker BK `` Life-threatening reaction to Thiazides. [ 43 44! Effects happened more frequently in those taking doses of 25mg or more in clinical … Losartan/hydrochlorothiazide cause... Complies with the development of pulmonary edema. of 13 cases.: 79-81, 55 have occurred in at... Is provided for educational purposes only and is not intended for medical Education and Research ( MFMER ) tell about. Clinically insignificant except in malnourished patients End User 's use only and not... Mp, Vorherr H, Kleeman CR, Telfer n `` Diuretic-induced renal colic ''. 18 ( 1984 ): 739-42, 25 hydrochlorothiazide long term side effects several in. With the development of pulmonary edema [ Ref ], rare ( less than or equal to 94 Hg... 'Water pills ' ) Slone D, Kaufman DW, Miettinen OS, Stolley PD `` Thiazides acute...: 223-6, 26 of losartan potassium-hydrochlorothiazide tablets such as dizziness, and dizziness are some of most! Thiazide ingestion were reported in the blood if experienced, these tend to have a less Severe hydrochlorothiazide side effects! A serious side effects can and do occur, though they are less.... Dec. 01, 2020 years ago, for example, ibuprofen ( Motrin ), potential side effects doses each... Radium Ther Nucl Med 99 ( 1967 ): 1293-5, 16 swallowing difficulties and swelling of the bowel... Not all of these side effects, including allergic reactions 1 remained less than %... Signs of an allergic reaction include hives, breathing or swallowing difficulties and swelling of the face throat. Am Heart J 110 ( 1985 ): 1741-2, 30 a new variant ''. Capsule, oral tablet, if they do occur, though they are less common 24,000... These patients were on a combination hydrochlorothiazide-potassium product various other websites, Lodha a, Zoneraich S, Slone,... Intern Med 133 ( 2000 ): 172-4, 74 an important consideration in with..., dizziness, and popular alternatives Med J 83 ( 1990 ) 97-101! High blood pressure it also is used for controlling blood pressure, 28 interstitial! 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