2010;66(2):127-136. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Nephron 1997;75(3):372. Clin Hemorheol.Microcirc. Memeo A, Loiero M. Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Maccio, A., Madeddu, C., Gramignano, G., Mulas, C., Floris, C., Sanna, E., Cau, M. C., Panzone, F., and Mantovani, G. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life. This medicine works best if you take it with a meal or within 30 minutes after a meal. Muscle carnitine deficiency associated with zidovudine-induced mitochondrial myopathy. Answer: Supplements including melatonin, tart cherry juice extract, L-tryptophan and 5-HTP, L-theanine, CBD (cannabidiol), ashwagandha, glycine, saffron, valerian, and possibly magnesium or Prevagen may, to varying degrees, improve sleep. Drugs Aging 2003;20:761-7. View abstract. View abstract. Am J Nephrol 1990;10(2):109-114. View abstract. View abstract. Carnitine, valproate, and toxicity. Does carnitine cause high blood pressure? Biochem Pharmacol 2003;65:1483-8.. View abstract. Goral S. Levocarnitine and muscle metabolism in patients with end-stage renal disease. View abstract. Skip the missed dose if it is almost time for your next scheduled dose. 2008;46(2):181-190. 2012;1:CD008427. View abstract. Call your doctor at once if you have: Common side effects of L-Carnitine may include: This is not a complete list of side effects and others may occur. 1991;13(1-2):135-146. View abstract. Pediatr.Nephrol. Gesuete, V., Ragni, L., and Picchio, F. M. [The "big heart" of carnitine]. This is not a complete list of side effects and others may occur. J NeuroAIDS. 2009;32(1):E13-E19. The effect of levocarnitine for plasmatic matrix metalloproteinases (MMPS) on acute cerebral infarct patients. DiMauro, S. and Hirano, M. Mitochondrial DNA Deletion Syndromes. View abstract. Invest Clin 2007;48(2):243-248. [Chronic fatigue syndrome and neurotransmitters]. l-Carnitine and heart disease - PubMed De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. B., Lagler, F., Maier, E. M., Schwahn, B., Tokatli, A., Dursun, A., Coskun, T., Chalmers, R. A., Koeller, D. M., Zschocke, J., Christensen, E., Burgard, P., and Hoffmann, G. F. Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency. Raskind JY, El-Chaar GM. Peivandi, S., Karimpour, A., and Moslemizadeh, N. Effects of L-carnitine on infertile men's spermogram; a randomized clinical trial. J Int.Soc.Sports Nutr. Helms, R. A., Whitington, P. F., Mauer, E. C., Catarau, E. M., Christensen, M. L., and Borum, P. R. Enhanced lipid utilization in infants receiving oral L-carnitine during long-term parenteral nutrition. Improved excercise tolerance after administration of carnitine. View abstract. 7 Best Creatine Supplements for Women in 2023: A Dietitians Picks. (56-58) L-carnitine levels may be decreased in hypothyroidism, potentially due to reduced synthesis of L-carnitine while we are in a . L-Carnitine may cause serious side effects. Acta Haematol. View abstract. Am.J Emerg.Med. Seong, S. H., Cho, S. C., Park, Y., and Cha, Y. S. L-carnitine-supplemented parenteral nutrition improves fat metabolism but fails to support compensatory growth in premature Korean infants. View abstract. 2020;151:104554. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. Ann Pharmacother 2000;34:630-8. Drugs Exper Clin Res 1983;9:925-934. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. View abstract. Biol Neonate 1990;58:81-8. 2008;29(2):261-266. 2014 May;29(5):997-1004. Cochrane.Database.Syst.Rev. View abstract. Hlais, S., Reslan, D. R., Sarieddine, H. K., Nasreddine, L., Taan, G., Azar, S., and Obeid, O. Wyss, V., Ganzit, G. P., and Rienzi, A. View abstract. Passeri M, Cucinotta D, Bonati PA, et al. Hi-Tech Pharmacal Company Inc (2022): 3. View abstract. View abstract. Acetylcarnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic . 2008;23(7):1602-1606. Sakurabayashi, T., Miyazaki, S., Yuasa, Y., Sakai, S., Suzuki, M., Takahashi, S., and Hirasawa, Y. L-carnitine supplementation decreases the left ventricular mass in patients undergoing hemodialysis. View abstract. O'Donnell, J., Finer, N. N., Rich, W., Barshop, B. Effect of l-carnitine supplementation on children and adolescents with nonalcoholic fatty liver disease (NAFLD): a randomized, triple-blind, placebo-controlled clinical trial. View abstract. 1) is a naturally occurring amino acid found in high concentrations in muscle, heart and brain tissues. View abstract. Novak M, Monkus EF, Buch M, and et al. A. N-carbamylglutamate for neonatal hyperammonaemia in propionic acidaemia. Insomnia; Our bodies partly metabolize carnitine into trimethylamine-N-oxide , which may promote plaque build-up in blood vessels . Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. Case report]. Pediatr.Hematol.Oncol. Neurobiol Aging 1995;16:1-4. Int J Clin Pharmacol Ther Toxicol 1985;23:569-72. Sekas G, Paul HS. Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma- butyrobetaine hydroxylase inhibitor. View abstract. G.Ital.Nefrol. Integr.Cancer Ther 2007;6(1):8-13. Effect of L-carnitine supplementation on renal anemia in patients on hemodialysis: a meta-analysis. It can also cause the urine, breath, and sweat to have a "fishy" odor. You may report side effects to FDA at 1-800-FDA-1088. Tomassini, V., Pozzilli, C., Onesti, E., Pasqualetti, P., Marinelli, F., Pisani, A., and Fieschi, C. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. View abstract. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. China Tropical Med 2007;7(5):753-754. Nikolaos, S., George, A., Telemachos, T., Maria, S., Yannis, M., and Konstantinos, M. Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients. The therapeutic effect of L-carnitine in patients with exercise-induced stable angina: a controlled study. Turpeinen AK, Kuikka JT, Vanninen E, and et al. You should not breast-feed while using L-Carnitine. J Nutr 2007;137(3 Suppl 2):847S-849S. View abstract. Sano M, Bell K, Cote L, et al. Acta Med Scand 1982;212(3):115-120. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. View abstract. View abstract. Brass, E. P., Hoppel, C. L., and Hiatt, W. R. Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans. The antagonistic effect of carnitine in hyperthyroidism. Perrott, J., Murphy, N. G., and Zed, P. J. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Bartels GL, Remme WJ, den Hartog FR, et al. Int J Clin Pharmacol.Ther Toxicol. 1999; Mitwalli, A. H., Al-Wakeel, J. S., Alam, A., Tarif, N., Abu-Aisha, H., Rashed, M., and Al, Nahed N. L-carnitine supplementation in hemodialysis patients. Zhonghua Er.Ke.Za Zhi. Increased urinary losses of carnitine during ifosfamide chemotherapy. View abstract. Mayo Clin Proc. Eur Heart J 1996;17:414-20. 12-3-1999;87(4):366-368. Pediatr.Neurol. Int J Sports Med 1994;15(4):181-185. View abstract. Hyperammonemia and carnitine deficiency in a patient receiving sulfadiazine and pyrimethamine. The highest concentrations are in high energy demand areas such as your brain, heart and muscles. Dig.Dis Sci 2008;53(11):3018-3025. 2007;18(8):533-540. View abstract. 2007;26(12):967-969. (Chinese) 2005;11:761-764. Moncada ML, Vicari E, Cimino C, et al. Acta Europ Fertil 1992;23:221-4. View abstract. 2010;29(4):312-34. J Inherit.Metab Dis 2008;31(4):503-507. nausea or vomiting Less common Abdominal discomfort body odor depression dizziness impaired vision loss of appetite or weight swelling in hands, lower legs, and feet tingling sensation weakness For Healthcare Professionals Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. View abstract. Clin Drug Invest 1996;11(2):90-96. The GOAL study. Management and outcome in 75 individuals with long-chain fatty acid oxidation defects: results from a workshop. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Drugs Exp Clin Res 1994;20:169-76. J Gastroenterol Hepatol 2019;34(12):2062-70. doi: 10.1111/jgh.14765. 2010;13(2):145-147. Best, Proven Brain Supplements (detailed guide) | Be Brain Fit Does left ventricular function improve with L-carnitine after acute myocardial infarction? Yet, there are a few known side effects that include agitation, insomnia and nausea. Clin Exp.Hypertens. View abstract. There is little evidence that L-carnitine supplementation improves cancer -related fatigue, low fertility, or overall physical health. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. Sunamori M, Nakagawa T, Fujisawa S, and et al. View abstract. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Relative carnitine deficiency in autism. Circulation 1988;77:767-73. Int J Clin Pharmacol Ther Toxicol 1988;26:217-20. Sulkers, E. J., Lafeber, H. N., Degenhart, H. J., Przyrembel, H., Schlotzer, E., and Sauer, P. J. 2010;20(11):693-700. 2007;44(2):83-90. One interesting observation is that ingestion of CoQ10 late in the evening might cause insomnia 15 and this may be due to increased energy levels. L-carnitine supplementation of a soybean-based formula in early infancy: plasma and urine levels of carnitine and acylcarnitines. L-Carnitine & Hypothyroidism | Healthfully Eur J Clin Pharmacol 1988;35(5):555-562. J Intern Med 1993;233:94. J Pediatr 1986;109(6):984-988. View abstract. J.HainanMed.College 2011;17(3):347-349. Call your doctor at once if you have: a seizure (convulsions). I. Carnitine concentrations and lipid effects. Calabrese, V., Cornelius, C., Stella, A. M., and Calabrese, E. J. 2010;(2):CD007280. Int Psychoger 1998;10:193-203. Metabolism 2010;59(8):1190-1199. View abstract. J Inherit.Metab Dis 9-10-2010; View abstract. Lancet 12-13-1980;2(8207):1309-1310. Bianchi, G., Vitali, G., Caraceni, A., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., and Gianni, L. Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Nutrition 2008;24(4):305-313. Lion's mane mushrooms: Benefits and side effects - Medical News Today Caruso U, Cravotto E, Tisone G, and et al. Freeman JM, Vining EPG, Cost S, Singhi P. Does carnitine administration improve the symptoms attributed to anticonvulsant medications? J Inherit.Metab Dis. J Infect Dis 1997;176:406-13. Eur J Obstet Gynecol Reprod Biol 2014;180:148-52. Drugs Exp Clin Res 1995;21(4):157-159. Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility. 2005-2023 Healthline Media a Red Ventures Company. View abstract. Sabry, A. 2000;2(2):189-193. Neri S, Pistone G, Saraceno B, et al. View abstract. View abstract. Pediatr.Res. J Inherit.Metab Dis 2006;29(2-3):288-298. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. 2007;22(6):330-337. Therefore, vegetarians and vegans may want to consider L-carnitine supplements. 2009;25(9):2223-2228. If given to patients on dialysis, 3 or more grams of L-carnitine daily might cause hypercalcaemia. View abstract. Endocr Metab Immune Disord Drug Targets 2020. In fact, in one study, a small group of people with hyperthyroidism saw these symptoms improve, and their body temperature become normal, when taking carnitine. Mettang, T., Thomas, S., and Kuhlmann, U. L-carnitine does not alleviate uremic pruritus in hemodialysis patients. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. Does carnitine cause insomnia? View abstract. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. View abstract. 2017;25(1):13-4. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. If you happen to feel nausea, next time just take this supplement with food or take a lesser dose. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. Mantovani G, Maccio A, Madeddu C, et al. View abstract. Int J Clin Pharmacol Res 1990;10(1-2):81-84. 2010;32(8):669-672. Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis. In specific cases, this form may even protect your brain from cell damage. Deeks SG, Collier A, Lalezari J, et al. Ye, J., Li, C. J., and Liu, J. H. [A clinical analysis of methylmalonic acidemia in adolescents]. Larsson, L. E., Olegard, R., Ljung, B. M., Niklasson, A., Rubensson, A., and Cederblad, G. Parenteral nutrition in preterm neonates with and without carnitine supplementation. Rajasekar, P. and Anuradha, C. V. L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management. 2010;20(6):711-723. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo. View abstract. View abstract. I noticed very sensitive teeth and gums for awhile, but seems to have . Ther Apher Dial 2020. Am.J Med.Genet.A 4-1-2008;146(7):803-812. Greig, C., Finch, K. M., Jones, D. A., Cooper, M., Sargeant, A. J., and Forte, C. A. View abstract. L-carnitine has most often been used by adults in doses of 2 grams by mouth daily. Sohn HJ, Choi GB Yoon KI. Dial Transplant 1998;27:498-506. Eur.Heart J 2007;28(5):608-612. Blood 1998;91:3817-24. J.Reprod.Infertil 2010;10(4):245-251. Background and aim: Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. [Reduction of hospitalization thanks to L-carnitine in hemodialyzed patients]. JPEN J Parenter.Enteral Nutr 1988;12(1):29-34. Am J Clin Nutr 1989;49(2):283-289. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. View abstract. [L-carnitine for the treatment of acute myocardial infarct]. Wolfe, L. A., He, M., Vockley, J., Payne, N., Rhead, W., Hoppel, C., Spector, E., Gernert, K., and Gibson, K. M. Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. Amino.Acids 2009;36(2):365-372. L-arginine should be used with caution. Tsoko M, Beauseigneur F, Gresti J, et al. Cuturic, M., Abramson, R. K., Moran, R. R., and Hardin, J. W. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. View abstract. Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. Fortin, G., Yurchenko, K., Collette, C., Rubio, M., Villani, A. C., Bitton, A., Sarfati, M., and Franchimont, D. L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. Kosolcharoen T, Nappi J, Peduzzi P, and et al. Effects of Carnitine on Thyroid Health - Thyroid Advisor View abstract. 1992;14(4):183-194. View abstract. Santo, S. S., Sergio, N., Luigi, D. P., Giuseppe, M., Margherita, F., Gea, O. C., Roberto, F., Gabriella, C., Giuseppe, P., and Massimiliano, A. View abstract. Am J Clin Nutr 1990;52(5):889-894. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. De Ritis G, Picardo S, Brancadoro D, and et al. Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. Cochrane.Database.Syst.Rev. Effects of wuzi yanzong liquids combing with L-carnitine on oligospermia and asthenospermia. Angiology 1989;40(10):857-862. Weigel, C., Kiener, C., Meier, N., Schmid, P., Rauh, M., Rascher, W., and Knerr, I. Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. View abstract. Postiglione A, Soricelli A, Cicerano U, et al. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. Ann Neurol 1988;24:301. 1. View abstract. Medical treatment to improve sperm quality. View abstract. Several conditions can cause bradycardia, including several potentially serious conditions, such as myocarditis, sleep apnea, lupus or certain medications. View abstract. Sood, A., Barton, D. L., Bauer, B. Clin Lymphoma Myeloma Leuk. View abstract. Sherif NA, El-Banna AS, ElBourini MM, Khalil NO. It can cause nausea, vomiting, stomach pain, weakness, and chest pain (angina). However, some individuals may experience digestive side effects when taking L-carnitine. View abstract. Efficacy of l-carnitine supplementation for management of blood lipids: A systematic review and dose-response meta-analysis of randomized controlled trials. Efficacy of L-carnitine and propranolol in the management of acute theophylline toxicity. View abstract. View abstract. 2010;21(7):580-588. 1996;24(4):251-255. Pettegrew, J. W., Levine, J., Gershon, S., Stanley, J. Int J Cardiol 1992;34(2):167-172. Hiraoka A, Kiguchi D, Ninomiya T, et al. However, popular claims about supplements dont always match up with the science.